


Local Rule Mechanism for Selecting Icosahedral Shell Geometry


Bonnie Berger, Jonathan King, Russell S. Schwartz, and Peter W. Shor




Local rules are given for various virus capsid, or protein shell,
geometries. Local rules specify local interaction patterns that can
direct the selfassembly of coat and scaffolding subunits into
different capsid geometries. They provide a mathematical abstraction
allowing combinatorial analysis of possible assembly pathways. Local
rules and simulations are provided for a geometry called "T=7" such
that a small change in the rules produces an alternate "T=4"
geometry. This is intriguing since evidence has been accumulating that
some "T=7" capsids are closely related to "T=4" capsids.





