Professor
Bonnie Berger

  Abstract
 

Paircoil2: Improved prediction of coiled coils from sequence

 
Andrew V. McDonnell, Taijiao Jiang, Amy E. Keating, and Bonnie Berger .
 

 

We introduce Paircoil2, a new version of the Paircoil program, which uses pairwise residue probabilities to detect coiled-coil motifs in protein sequence data. Paircoil2 achieves 98% sensitivity and 97% specificity on known coiled coils in leave-family-out cross-validation. It also shows superior performance compared with published methods in tests on proteins of known structure.

 URL:http://bioinformatics.oxfordjournals.org