Adaptive Clinical Trial Designs, by Michael Rosenblum
Slides from Lecture and R Files
Slides from first three lectures (introduction, FDA draft guidance, group sequential designs, and adaptation of randomization probabilities)
R Code for generating sample paths of estimated risk difference
R Code for Some Covariate-Adaptive Simulations
Interesting, Related Articles (Optional Reading)
Drug Researchers Leak Secrets to Wall St.
Active Placebos vs. Antidepressants
Last modified: Fri Apr 23 16:13:09 EDT 2010