Adaptive Clinical Trial Designs, by Michael Rosenblum

Link to Syllabus

List of Readings, with Links to Papers

Slides from Lecture and R Files

Slides from first three lectures (introduction, FDA draft guidance, group sequential designs, and adaptation of randomization probabilities)

R Code for generating sample paths of estimated risk difference

R Code for Some Covariate-Adaptive Simulations

Interesting, Related Articles (Optional Reading)

Drug Researchers Leak Secrets to Wall St.

Active Placebos vs. Antidepressants
Last modified: Fri Apr 23 16:13:09 EDT 2010