Charles W. O'Donnell




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I am a computational biologist at Biogen Idec leading the Epigenetics group's next-gen sequencing analysis efforts as well as networks analysis work [Profile].

Before joining Biogen Idec I was a joint Postdoctoral Fellow in the labs of Douglas Melton at the Harvard Stem Cell Institute and David Gifford. at MIT. There I applied diverse NGS-based assays to study chromatin dynamics and the epigenetic regulation of pluripotent cells during differentiation - identifying novel mechanisms and factors controlling cell state change and developing new methods for studying heterogeneous cell populations.

I completed my Ph.D. at MIT, in the labs of Bonnie Berger and Srini Devadas, and Susan Lindquist at the Whitehead Institute for Biomedical Research. There I developed algorithms to characterize the folding and misfolding of proteins and RNA, and for modeling the inhibition of amyloid fibril formation.