Research
I
have participated in a variety of research projects on statistical
analysis of
brain structures and computer-aided diagnosis based on magnetic
resonance
images in the Athinoula
A. Martinos Center
for Biomedical Imaging at Massachusetts
General
Hospital.
I work with Bruce
Fischl (thesis advisor), Polina
Golland and Bruce
Rosen. The goal of my thesis work is to develop an automated
procedure for
detecting and modeling morphological changes of neuroanatomical
structures associated with neurodevelopment and various neurological
diseases
for accurate diagnosis and proper treatments. To this end, I have
developed and
applied techniques in different areas, including medical image
analysis,
computer vision, and statistical machine learning, to solve problems in
medical
image analysis applications. Please see details in my CV.
Publications
H.D. Rosasa, S.Y.
Leea, A.C. Bendera, A.K. Zaletaa, M. Vangelc, P. Yu, et al, Altered white
matter microstructure in the corpus callosum in Huntington's disease:
Implications for cortical "disconnection", Neuroimage, 49(4):2995-3004,
2010.
M.I. Miller, C.E.
Priebe, A. Qiu, B. Fischl, A. Kolasny, T. Brown, Y. Park, J.T.
Ratnanather, E.
Busa, J. Jovicich, P. Yu, B.C.
Dickerson, R.L. Buckner, Morphometry
BIRN,Collaborative computational anatomy: an MRI morphometry study of
the human
brain via diffeomorphic metric mapping, Human Brain Mapping,
30(7):2132-2141,
2009.
B.T.T. Yeo, P.
Yu, P.E. Grant, B. Fischl1, P. Golland, Shape Analysis with
Overcomplete
Spherical Wavelets, Medical Image Computing and Computer-Assisted
Intervention
(MICCAI 2008), Lecture Notes in Computer Science, Volume 5241:468-476,
2008.
P.
Yu, B.T.T.
Yeo, P.E. Grant, B. Fischl, P. Golland, Cortical Folding Development
Study
Based On Over-complete Spherical Wavelets, Proceedings of the IEEE 11th
International Conference on Computer Vision, Issue 14-21: 1-8, 2007.
P.
Yu, et al., Cortical Surface Shape Analysis Based on Spherical
Wavelets, IEEE Transaction on Medical Imaging, 26(4):582-598, 2007 PDF
P. Yu,
X. Han, F.
Segonne, A. K. Liu, R. A. Poldrack, P. Golland, and B. Fischl,
Shape-based
Discrimination and Classification of Cortical surface. Proceedings of
the 18th
International Conference on Pattern Recognition, Volume 3: 445-448,
2006.PDF
P. Yu,
X. Han, F.
Segonne, R. L. Buckner, R. Pienaar, P. Golland, P. E. Grant and B.
Fischl,
Cortical Surface Shape Analysis Based on Spherical Wavelet
Transformation.
Conference on Computer Vision and Pattern Recognition Workshop (CVPRW
'06),
Issue 17-21: 60-67, 2006. PDF
P. Yu,
F.
Segonne, X. Han, B. Fischl, Shape Analysis of Neuroanatomical
Structures Based
on Spherical Wavelets. Neuroimage, Volume 26, Suppl 1, Page S47,
Organization
for Human Brain Mapping Annual Meeting, 2005.
P. Yu, D.H.
Salat, P. Golland, D. S. Tuch, H. D. Rosas, B. Fischl, Subdividing the
Corpus
Callosum Based on Morphometry and Diffusion Anisotropy. International
Society
for Magnetic Resonance in Medicine (ISMRM), 2005.
H.D. Rosas, P.
Yu, Tuch, Hevelone, D.H. Salat, B. Fischl, Pathological
alterations of the
Corpus Callosum in Huntington's Disease: a combined DTI and
Morphometric Study.
Neuroimage Volume 26, Suppl 1, Page S21, Organization for Human Brain
Mapping
Annual Meeting, 2005.
D.H.
Salat, P.
Yu, D.S. Tuch, N.D. Hevelone, B. Fischl, H.D. Rosas, Detailed
Analysis of
Age-related Changes in he Corpus Calllosum: Combined DTI and
Morphometric MRI.
Neuroimage, Volume 26, Suppl 1, Page S47, Organization for Human Brain
Mapping
Annual Meeting, 2005.
Beg, R.L.
Buckner, B. Fischl, Y. Park, Ceyhan, C.E. Priebe, Beritoglu, Kolasny,
T. Brown,
B. Quinn, P. Yu, et al.,
Patten classification of hippocampal shape analysis in
a study of Alzheimer's Disease. Neuroimage, Volume 26, Suppl 1, Page
S39, Organization
for Human Brain Mapping Annual Meeting, 2005.
Teaching
Applied
Nuclear Physics: Assisted in preparing course materials and grading
homework;
organized weekly recitations, reviews, and office hours.
Nuclear Engineering Laboratory: Instructed labs and graded lab reports.
In
the media
Our research
work in reported by:
MIT Tech Talk Model helps
researchers 'see' brain development
Chinese
Xinhua news agency http://news.xinhuanet.com/world/2007-04/13/content_5972192.htm
United Press International Scientists
seek 'see' brain
development
HMS Focus HST
Forum: Decoding Health and Disease
http://www.medicalnewstoday.com
http://www.medilexicon.com
http://www.hospitalsworldwide.com
Misc
MIT Tech Dumpling
Making