Danielle F. Pace

Danielle F. Pace

Senior Machine Learning Scientist
Machine Learning for Health
The Broad Institute

I am a Senior Machine Learning Scientist with the Machine Learning for Health team at the Broad Institute.

I received my PhD in Computer Science in 2020 from the Massachusetts Institute of Technology (MIT), advised by Polina Golland. I then joined the A.A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital as a Research Fellow, advised by Adrian Dalca and Bruce Fischl.

Previously, I was an R&D Engineer at Kitware, Inc. for three years. I received my Master's in Biomedical Engineering from the University of Western Ontario in London, Ontario, Canada, and my Bachelor's in Biomedical Computing from Queen's University in Kingston, Ontario, Canada.

Publications

 See my Google Scholar page.

Peer-reviewed journal articles

  • HVSMR-2.0: A 3D cardiovascular MR dataset for whole-heart segmentation in congenital heart disease
    D.F. Pace, H.T.M Contreras, J. Romanowicz, S. Ghelani, I. Rahaman, Y. Zhang, P. Gao, M.I. Jubair, T. Yeh, P. Golland, T. Geva, S. Ghelani, A.J. Powell, M.H. Moghari
    Nature Scientific Data; 11:721, 2024 [Link] [PDF]
  • Non-invasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping
    V. Nauffal, M.D.R. Klarqvist, M.C. Hill, D.F. Pace, P. Di Achille, S.H. Choi, J.T. Rämö, J.P. Pirruccello, P. Singh, S. Kany, C. Hou, K. Ng, A.A. Philippakis, P. Batra, S.A. Lubitz, P.T. Ellinor
    Nature Medicine; 30:1749-1760, 2024 [Link] [PDF]
  • Automated segmentation of 3D cine cardiovascular magnetic resonance imaging
    S.T. Arasteh, J. Romanowicz, D.F. Pace, P. Golland, A.J. Powell, A.K. Maier, D. Truhn, T. Brosch, J. Weese, M. Lotfinia, R.J. van der Geest, M.H. Moghari
    Frontiers in Cardiovascular Medicine; 10, 2023 [Link] [PDF]
  • Learned iterative segmentation of highly variable anatomy from limited data: Applications to whole heart segmentation for congenital heart disease
    D.F. Pace, A.V. Dalca, T. Brosch, T. Geva, A.J. Powell, J. Weese, M.H. Moghari, P. Golland
    Medical Image Analysis; 80:102469, 2022 [Link] [PDF]
  • Anatomy-aware inference of the 3D standing spine posture from 2D radiographs
    A. Bayat, D.F. Pace, A. Sekuboyina, C. Payer, D. Stern, M. Urschler, J.S. Kirschke, B.H. Menze
    Tomography; 8(1):479-496, 2022 [Link] [PDF]
  • Segmentation of tricuspid valve leaflets from transthoracic 3D echocardiograms of children with hypoplastic left heart syndrome using deep learning
    C. Herz, D.F. Pace, N.H. Nam, A. Lasso, P. Dinh, P. Golland, M.A. Jolley
    Frontiers in Cardiovascular Medicine; 8, 2021 [Link] [PDF]
  • A locally adaptive regularization based on anisotropic diffusion for deformable image registration
    D.F. Pace, S.R. Aylward, M. Niethammer
    IEEE Transactions on Medical Imaging; 32(11): 2114-2126, 2013 [Link] [PDF]
  • Multimodal neuroimaging of structural pathology and neuroconnectivity in traumatic brain injury: towards personalized outcome prediction
    A. Irimia, B. Wang, S. Aylward, M. Prastawa, D.F. Pace, M. Niethammer, G. Gerig, D.A. Hovda, R. Kikinis, P.M. Vespa, J.D. Van Horn
    NeuroImage: Clinical; 1(1):1-17, 2012 [Link] [PDF]

Peer-reviewed conference proceedings

  • Iterative segmentation from limited training data: Applications to congenital heart disease
    D.F. Pace, A.V. Dalca, T. Brosch, T. Geva, A.J. Powell, J. Weese, M.H. Moghari, P. Golland
    MICCAI Workshop on Deep Learning in Medical Image Analysis, 2018 [Link] [PDF]
  • Interactive whole-heart segmentation in congenital heart disease
    D.F. Pace, A.V. Dalca, T. Geva, A.J. Powell, M.H. Moghari, P. Golland
    MICCAI: Medical Image Computing and Computer Assisted Interventions, 2015 [Link] [PDF]
  • Studying cerebral vasculature using structure proximity and graph kernels
    R. Kwitt, D.F. Pace, M. Niethammer, S.R. Aylward
    MICCAI: Medical Image Computing and Computer Assisted Interventions, 2013 [Link] [PDF]
  • Sliding geometries in deformable image registration
    D.F. Pace, M. Niethammer, S.R. Aylward
    MICCAI Workshop on Computational and Clinical Applications in Abdominal Imaging, 2011 [Link] [PDF]
  • Geometric Metamorphosis
    M. Niethammer, G.L. Hart, D.F. Pace, P.M. Vespa, A. Irimia, J.D. Van Horn, S.R. Aylward
    MICCAI: Medical Image Computing and Computer Assisted Interventions, 2011 [Link] [PDF]
  • Deformable image registration of sliding organs using anisotropic diffusive regularization
    D.F. Pace, A. Enquobahrie, H. Yang, S.R. Aylward, M. Niethammer
    ISBI: IEEE International Symposium on Biomedical Imaging, 2011 [Link] [PDF]
  • Ultrasound image guidance of cardiac interventions
    T. Peters, D.F. Pace, P. Lang, G. Guiraudon, D. Jones, C. Linte
    SPIE Medical Imaging, 2011 [Link] [PDF]
  • Estimating heart shift and morphological changes during minimally invasive cardiac interventions
    C.A. Linte, M. Carias, S.D. Cho, D.F. Pace, J. Moore, C. Wedlake, D. Bainbridge, B. Kiaii, T.M. Peters
    SPIE Medical Imaging, 2010 [Link] [PDF]
  • An open-source real-time ultrasound reconstruction system for four-dimensional imaging of moving organs
    D.F. Pace, D.G. Gobbi, C. Wedlake, J. Gumprecht, J. Boivert, J. Tokuda, N. Hata, T.M. Peters
    MICCAI Workshop on Systems and Architectures for Computer Assisted Intervention, 2009 [Link] [PDF]
  • Image guidance for spinal facet injections using tracked ultrasound
    J. Moore, C. Clarke, D. Bainbridge, C. Wedlake, A.D. Wiles, D.F. Pace, T.M. Peters
    MICCAI: Medical Image Computing and Computer Assisted Interventions, 2009 [Link] [PDF]
  • Cardiac imaging and modeling for guidance of minimally invasive beating heart interventions
    T.M. Peters, C.A. Linte, J. Moore, A. Wiles, J. Lo, D.F. Pace, C. Wedlake, D. Bainbridge, D.L. Jones, G.M. Guiraudon
    FIMH: Functional Imaging and Modeling of the Heart, 2009 [Link] [PDF]
  • Validation of four-dimensional ultrasound for targeting in minimally-invasive beating-heart surgery
    D.F. Pace, A.D. Wiles, J. Moore, C. Wedlake, D.G. Gobbi, T.M. Peters
    SPIE Medical Imaging, 2009 [Link] [PDF]
  • An open-source framework for testing tracking devices using Lego Mindstorms™
    J. Jomier, L. Ibanez, A. Enquobahrie, D.F. Pace, K. Cleary
    SPIE Medical Imaging, 2009 [Link] [PDF]
  • An accessible, hands-on tutorial system for image-guided therapy and medical robotics using a robot and open source software
    D.F. Pace, R. Kikinis, N. Hata
    MICCAI Workshop on Open Source and Open Data, 2007 [Link] [Tutorial Website] [PDF]

Peer-reviewed conference abstracts

  • Creating 3D heart models of children with congenital heart disease using magnetic resonance imaging
    D.F. Pace, Polina Golland, David Annese, Tal Geva, Andrew J. Powell, M.H. Moghari
    ISMRM: International Society for Magnetic Resonance in Medicine, 2015 [PDF]
  • Anthropometric differences in natural posterior tibial slope
    Y. Dai, D.F. Pace, J. Bischoff
    ORS: Orthopaedic Research Society, 2014 [PDF]
  • TubeTK: An open-source toolkit of algorithms operating on images of tubes
    D.F. Pace, A. Enquobahrie, P. Reynolds, J. Jomier, E. Bullitt, S.R. Aylward
    CARS: Computer Assisted Radiology and Surgery, 2012 [PDF]
  • Real-time 4D ultrasound reconstruction for improved intraoperative imaging during image-guided beating-heart interventions
    D.F. Pace, D. Bainbridge, J. Moore, C. Wedlake, G. Guiraudon, D.L. Jones, T.M. Peters
    CARS: Computer Assisted Radiology and Surgery, 2010 [PDF] [ISCAS Best Poster award]
  • Estimating heart movement and morphological changes during robot-assisted coronary artery bypass graft interventions
    C.A. Linte, D.S. Cho, M. Carias, D.F. Pace, J. Moore, C. Wedlake, D. Bainbridge, B. Kiaii, T.M. Peters
    CARS: Computer Assisted Radiology and Surgery, 2010 [PDF]
  • Computational estimates of the effect of asynchronous synaptic activity on fluctuations in the membrane potential of motoneurons
    D.F. Pace, T. Bui, P.K. Rose
    SfN: Society for Neuroscience, 2006 [PDF] [Poster]

Theses

  • Image segmentation for highly variable anatomy: Applications to congenital heart disease
    D.F. Pace
    Ph.D. Thesis, Massachusetts Institute of Technology, 2020 [PDF]
  • Real-time 4D ultrasound reconstruction for image-guided intracardiac interventions
    D.F. Pace
    M.E.Sc. Thesis, University of Western Ontario, 2010 [PDF]

Books and Proceedings

  • Reconstruction, segmentation and analysis of medical images
    M.A. Zuluaga, K. Bhatia, B. Kainz, M.H. Moghari, D.F. Pace (editors)
    First International Workshops, RAMBO 2016 and HVSMR 2016 [Link]